| Title: | Identification of genetic variants and lifestyle factors involved in obesity. |
| Lead Institution: | Southwest Jiaotong University |
| Principal investigator: |
Application 93810
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About
Obesity is characterized by the excessive accumulation of the white adipose tissue and is considered to be driven by genetic, environmental and lifestyle factors. We aim to identify genetic factors and lifestyle factors including dietary pattern, sleeping and physical activity involved in obesity. For this purpose, a genome-wide exploratory approach will be utilized to identify new genetic variants and gene-environment interactions that predispose higher body mass, higher body adiposity and risk of obesity. In this study, we need the data of UKB to explore 1) the associations of different dietary patterns with risk of obesity; 2) potential influence of sleeping quality and duration on risk of developing obesity; 3) the risk of obesity associated with physical activities; 4) new gene variants and gene-environment interactions that predispose overweight and obesity. This project will take approximately 3 years to analyse all the data and write the results for publication.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9850 | Association of air pollution with incidence of late-onset seborrhoeic dermatitis: a prospective cohort study in UK Biobank | Peng Chen (+6) | 2024 | Clinical and Experimental Dermatology |
| 12080 | Association of biological age acceleration with cardiac morphology, function, and incident heart failure: insights from UK Biobank participants | Rui Mao (+5) | 2024 | European Heart Journal - Cardiovascular Imaging |
| 9349 | Association of cholecystectomy with osteoporosis risk: a prospective study using data from the UK Biobank | Qin Yang (+5) | 2023 | Frontiers in Endocrinology |
| 12813 | Associations of biological age accelerations and genetic risk with incident endometrial cancer: a prospective analysis in UK Biobank. | Ziye Yang (+4) | 2024 | International Journal of Surgery |
| 12952 | Genetic association of lipid and lipid-lowering drug target genes with atopic dermatitis: a drug target Mendelian randomization study | Qinwang Niu (+4) | 2024 | Scientific Reports |
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