| Title: | Evaluation of polygenic risk prediction in the development of age-related disease between different ethnicity: comparison of East Asians and Europeans |
| Lead Institution: | Seoul National University Hospital |
| Principal investigator: |
Application 91312
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
Precision medicine is the emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person. Recent technological advances have improved the accuracy and lowered the price for reading one's genetic information, which made it possible to read large numbers of genetic information in depth. Moreover, it has been known that genetic factors contribute differently by different ethnicities. We aim to find novel genes that are responsible for age-related diseases such as cancer and find ways to utilize this genetic information in predicting disease development and prognosis. Next, we will combine genetic information and metabolic phenotypes to build a multivariate longitudinal model, then perform comparative analysis between KoGES cohort (East Asian population) and UK Biobank (European population). We hope these findings will help understanding genetic architecture of two different ethnicities, realization of precision medicine and improve aging health by providing strategies for tailored prevention.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9782 | Alcohol is neither a risk factor nor a protective factor for sudden cardiac death and/or fatal ventricular arrhythmia; a population-based study with genetic traits and alcohol consumption in UK Biobank | Chan Soon Park (+9) | 2024 | Heart Rhythm |
| 9081 | Risk of newly developed atrial fibrillation by alcohol consumption differs according to genetic predisposition to alcohol metabolism: a large-scale cohort study with UK Biobank | Chan Soon Park (+9) | 2023 | BMC Medicine |
Enabling scientific discoveries that improve human health