| Title: | Elucidating the etiology and the treatment target of complex diseases by integrating genome and metabolome data |
| Lead Institution: | Massachusetts General Hospital |
| Principal investigator: |
Application 88976
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About
This proposal will use UK Biobank data to understand how important genes and metabolites are to diseases (such as asthma, diabetes, and dementia) and how such effects might vary by environmental factors (e.g., dietary habits, physical activity, air pollution). Diseases are often affected by many genes and compounds. Especially, compounds measured by metabolomics (a test of many metabolites) are influenced by the effect of both genetic and environmental factors. Metabolomics is a comprehensive analysis of the group of small molecules (such as sugars, amino acids, and lipids), which helps us gain knowledge of disease mechanisms. While many studies have studied the role of genetics in diseases, few have evaluated the combined role of genetic risk factors and metabolites in diseases. To address the major knowledge gap, we will analyze genetics and metabolomics data together to deepen our understanding of the genetic and metabolic effects of diseases. We expect the project will be completed in 2-3 years, but it might be extended because of new findings and the development of new methods. Through the proposed project, we hope to provide the public with a better understanding of the disease risk and mechanisms, new treatment targets for the diseases, and novel scores predicting the risk and severity of the diseases. Our findings with this project will also contribute to the public by accelerating the development of prevention strategies and precision medicine for diseases.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 11037 | Integrative genetics-metabolomics analysis of infant bronchiolitis-childhood asthma link: A multicenter prospective study | Tadao Ooka (+9) | 2023 | Frontiers in Immunology |
Enabling scientific discoveries that improve human health