| Title: | Integration of clinical data and genomic data to construct diagnosis and prognosis system for digestive diseases and related complications |
| Lead Institution: | First Hospital of Jilin University |
| Principal investigator: | Professor Guo Yue Lv |
Application 84347
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About
1. Aims: We aims to establish the diagnosis and prognosis system for digestive diseases and related complications using genotype and phenotype data, enhancing the translation from basic research to clinical application. 2. Scientific rationale: Digestive diseases and related complications constitute a large part of human diseases. However, the precise diagnosis and prognosis system for digestive disease are still far from satisfactory. Accumulating evidence has suggested the integration of genotype and phenotype data could improve the specificity and sensitivity of diagnosis and prognosis of certain diseases. 3. Project duration: Three years will be needed to complete this project. 4. Public health: An improved guidance on diagnosis and prognosis of digestive diseases and related complications would be provided for the benefits of public health. Besides, a preventive guideline for digestive diseases and related complications would be provided as well.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 7995 | A study of factors impacting disease based on the Charlson Comorbidity Index in UK Biobank | Changcong Wang (+3) | 2023 | Frontiers in Public Health |
| 11944 | Antioxidant insights: investigating the protective role of oxidative balance in inflammatory bowel disease | Fan Li (+13) | 2024 | Frontiers in Endocrinology |
| 8645 | Appraising associations between signature lipidomic biomarkers and digestive system cancer risk: novel evidences from a prospective cohort study of UK Biobank and Mendelian randomization analyses | Yuanlin Sun (+8) | 2024 | Lipids in Health and Disease |
| 8707 | Association between liver enzymes and type 2 diabetes: a real-world study | Yaru Bi (+7) | 2024 | Frontiers in Endocrinology |
| 9786 | Oxidative balance score: a potential tool for reducing the risk of colorectal cancer and its subsites incidences | Yu Chang (+13) | 2024 | Frontiers in Endocrinology |
Enabling scientific discoveries that improve human health