| Title: | Research on the association of different environments and genetic backgrounds on sex-specific disease |
| Lead Institution: | Guangxi Medical University |
| Principal investigator: | Dr Xiaobo Yang |
Application 81124
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About
The association between gene-environment and environment-environment and sex differences disease remains inconclusive and complex. We aim to explore the complex association between them. A wide range of risk factors (lifestyle, psychological factors, socioeconomic, environmental, anthropometric factors) are closely related to health-related outcomes. We intended to combine exposure factors (lifestyle, psychological factors, socioeconomic, environmental, anthropometric factors) and genetic factors to explore the gene-environment and environment-environment interaction. By accessing the UK biobank and using the whole cohort we can explore the association between sex differences disease and lifestyle, psychological factors, socioeconomic, environmental, anthropometric factors. A better understanding of the gene-environment interaction would enable the prevention of diseases, direct the launch of proper clinical trials and provide targets for effective lifestyle and pharmacological interventions. We propose to complete this project in 36 months.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 10765 | Association Between Genetic Risk, Adherence to Healthy Lifestyle Behavior, and Thyroid Cancer Risk | Xiuming Feng (+11) | 2022 | JAMA Network Open |
Enabling scientific discoveries that improve human health