| Title: | Development and validation of polygenic risk scores for coronary heart disease and related risk factors in diverse racial/ethnic groups |
| Lead Institution: | Mayo Clinic |
| Principal investigator: | Dr Iftikhar Kullo |
Application 79990
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About
Risk scores that are made up of genetic markers in the human genome, i.e. polygenic risk scores (PRS), have been shown to identify individuals at 2-3 times higher risk of heart disease. However, application of these scores to racial/ethnic minorities is challenging since PRS were developed using white participants. Genetic differences across racial/ethnic groups require development/validation of PRS specifically for minority racial/ethnic groups to achieve the same level of performance. In this study, we aim to use UK Biobank and several other ancestrally diverse cohorts to develop/validate PRS for CHD that have high performance across a wide range of ancestry groups including individuals who are admixed. This will allow accurate characterization of the genetic risk of heart and blood vessel diseases and better risk estimations for ethnically diverse groups.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9475 | A linear weighted combination of polygenic scores for a broad range of traits improves prediction of coronary heart disease | Kristjan Norland (+2) | 2023 | European Journal of Human Genetics |
| 9665 | Polygenic Risk, Rare Variants, and Family History Independent and Additive Effects on Coronary Heart Disease | Seyedmohammad Saadatagah (+5) | 2023 | JACC Advances |
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