| Title: | How Socioeconomic Status Affects the Causal Association Between BMI and Cardiovascular Disease: A Mendelian Randomization Analysis. |
| Lead Institution: | University of California, Berkeley |
| Principal investigator: | Professor William Dow |
Application 79654
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About
We have a limited understanding of how body mass index (BMI) and low socioeconomic status (SES) contribute to an individual's cardiovascular disease (CVD) risk. Our study uses genetic and socioeconomic factors to understand the mechanisms through which the social determinants of health like income and educational attainment interact with high BMI, a more traditional CVD risk factor, to contribute to a person's risk of CVD. Ultimately, this project will have a public health benefit by demonstrating how directly targeting upstream social factors such as income and education or downstream factors such as modifiable health behaviors and medical care access and utilization would produce the greatest CVD risk reduction among people living with low SES backgrounds with high BMI.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 7969 | Does educational attainment modify the causal relationship between adiposity and cardiovascular disease? A Mendelian randomization study | Robert C. Schell (+4) | 2023 | SSM - Population Health |
| 11864 | Joint association of genetic risk and accelerometer-measured physical activity with incident coronary artery disease in the UK biobank cohort | Robert C. Schell (+4) | 2024 | PLOS ONE |
Enabling scientific discoveries that improve human health