| Title: | Gene-Environment Interactions of complex diseases based on big data analysis |
| Lead Institution: | Hangzhou Normal University |
| Principal investigator: | Ms Claire Wu |
Application 78563
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About
Many complex diseases, such as cancers, hypertension, diabetes, sensorineural hearing loss and so on, are known to be controlled by a complex interplay of both genetic and lifestyle factors. To reveal the extent to which increased genetic risk can be offset by a healthy lifestyle requires a large sample size, such as promised by UK Biobank. AIMs: This study aims to test the hypothesis that genetic risk of specific disease, such as cancers, hypertension, diabetes and so on, might be attenuated by a favorable lifestyle. We then exam the extent to which a healthy lifestyle is associated with a reduced risk of specific disease among participants with a high genetic risk. Scientific rationale: Much evidence has also shown that people who adhere to a healthy lifestyle have markedly reduced rates of cancers and cardiovascular events, the promotion of healthy lifestyle behaviors, which include not smoking, avoiding obesity, regular physical activity, a healthy diet pattern, et al, underlies the current strategy to improve health in the general population. However, the extent to which increased genetic risk can be offset by a healthy lifestyle is unknown. Large sample size is important for scientific discovery, especially for complex human diseases. However, many available cohorts have sample size less than 10,000, which hampers scientific discovery. As a large prospective database, UK Biobank provides many opportunities to find the associations between genetic and lifestyle behaviors of complex disease risk. Project duration: it is sufficient for 3 years. It takes 1 year to realize and test the genetic-lifestyle interactions of complex diseases in computer codes. Another year is required to analyze the UK Biobank data thoroughly. The third year will be spent writing a report for our discovery. Public health impact: This prospective cohort study will provide quantitative data on how genetic risk, lifestyle behaviors, and their interactions with the risk of complex disease. Patients may equate DNA-based risk estimates with determinism, a perceived lack of control over the ability to improve outcomes. However, our results aim to provide evidence that lifestyle factors may powerfully modify risk regardless of the patient's genetic risk profile. The results are beneficial to carry out primary prevention of complex disease.4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 12277 | Association of a Healthy Lifestyle with All-Cause, Cause-Specific Mortality and Incident Cancer among Individuals with Metabolic Syndrome: A Prospective Cohort Study in UK Biobank | E Wu (+5) | 2022 | International Journal of Environmental Research and Public Health |
| 11469 | Association of serum 25-hydroxyvitamin D with the incidence of 16 cancers, cancer mortality, and all-cause mortality among individuals with metabolic syndrome: a prospective cohort study | E Wu (+6) | 2023 | European Journal of Nutrition |
| 8263 | Association of tea and coffee consumption with the risk of all-cause and cause-specific mortality among individuals with metabolic syndrome: a prospective cohort study | E Wu (+9) | 2023 | Diabetology & Metabolic Syndrome |
| 10550 | Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen | E. Wu (+6) | 2022 | Frontiers in Oncology |
Enabling scientific discoveries that improve human health