| Title: | Genetic and Multi-Omics Analysis of Aspiration Pneumonia Risk in UK Biobank |
| Lead Institution: | Fudan University |
| Principal investigator: |
Application 778067
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About
Aspiration pneumonia, caused by inhalation of foreign material into the lungs, is a significant health burden, particularly among the elderly, yet its molecular basis remains poorly understood. UKB offers a unique opportunity to study this condition with its large cohort (500,000 participants), detailed health records (e.g., ICD-10 J69.0 in Field 41270), and rich omics data (genomics, proteomics, metabolomics). Genetic studies suggest heritability in lung diseases, but aspiration pneumonia-specific variants are underexplored. Proteomic and metabolomic analyses can reveal biomarkers of inflammation or metabolic dysfunction tied to aspiration events. Integrating these data may uncover novel pathways, enhancing prevention and treatment strategies. This research leverages UKB's hospital-linked data and omics resources to address a critical gap in respiratory disease research.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 20064 | A cumulative-morbidity plasma proteomic architecture of critical-illness susceptibility: a UK biobank proteome-wide study of critical-care exposure, in-hospital death, and sex-specific signals | Xingxing Ren (+2) | 2026 | Journal of Intensive Care |
| 19909 | Multi-dimensional risk prediction and genetic architecture of aspiration pneumonia: a population-based analysis | Chaoyuan Jin (+3) | 2026 | BMC Infectious Diseases |
Enabling scientific discoveries that improve human health