| Title: | Systematic Screening of Risk Factors for Bone and Joint Diseases |
| Lead Institution: | Soochow University |
| Principal investigator: | Dr Lin Bo |
Application 76875
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About
Osteoporosis (OP) and rheumatoid arthritis (RA) are two main bone&joint diseases that cause disability and death especially in old people. There exist many complex genetic and environmental factors in determining the occurrence of these diseases. However, the specific risk factors for OP and RA is still largely unknown. Here, we propose this 3-year project to find the unknown specific risk factors associated with osteoporosis/RA using a large database from the UK Biobank. The new and advanced methods and strategies have genetic risk score (GRS), Mediation analysis, gene-environment analysis and GRS&environment interaction. This project will improve our understanding on which risk factors related to these diseases. The detected risk factors will rich the pathogenesis picture, and also provide new insights for prevention, clinical treatment, and prognosis of osteoporosis/RA in a more comprehensive manner.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9810 | Accelerated biological aging as a potential risk factor for rheumatoid arthritis | Yi-Lin Dan (+4) | 2024 | International Journal of Rheumatic Diseases |
| 11223 | Air pollution, genetic factors and the risk of osteoporosis: A prospective study in the UK biobank | Xing-Hao Yu (+4) | 2023 | Frontiers in Public Health |
| 7402 | Genetic Risk for Osteoporosis and the Benefit of Adherence to Healthy Lifestyles | Yi-Qun Yang (+4) | 2022 | International Journal of Public Health |
| 12823 | Inflammatory bowel disease and osteoporosis: Common genetic effects, pleiotropy, and causality | Ya-Qi Hu (+4) | 2024 | Human Immunology |
| 7091 | Systematic Evaluation of Rheumatoid Arthritis Risk by Integrating Lifestyle Factors and Genetic Risk Scores | Xing-Hao Yu (+6) | 2022 | Frontiers in Immunology |
Enabling scientific discoveries that improve human health