| Title: | Systemic evaluation of the Associations of environmental factors with the risk of mortality and morbidity |
| Lead Institution: | Fujian Medical University |
| Principal investigator: | Dr Xiaoxu Xie |
Application 75905
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About
We aim to use the unprecedented power and richness of data in UK Biobank to explore the relationship and underlying mechanisms between varied types of environmental exposure (e.g. air pollution, heat wave, noise, and surrounding environment) and health outcomes. Epidemiological studies have linked numerous environmental factors with risk of multiple chronic diseases and death. However, virtually no studies have been done to systematically evaluate the relationships between environmental factors and risk of all chronic diseases and death. Meanwhile, few past studies have used genetic information to assess the causal nature of any association. Furthermore, the modifier, mediator, and underlying biological mechanisms of environmental exposures impact on health remain unclear. To address these issues, we will use data from UK Biobank to conduct prospective observational analyses, mediation analyses, phenome-wide association analyses, genome-wide association analyses, mendelian randomization analyses, and metabolomics analyses. We anticipate that these analyses will: 1) characterise and compare the associations of environmental factors with various traits and diseases; 2) check whether other characteristics (socioeconomic status, lifestyles, biomarkers) can modify or mediate the health effects of environmental exposures; 3) identify the causal effect of environmental exposures on health outcomes; and 4) reveal potential metabolic pathways and biological mechanisms whereby environmental risk factors increase mortality and morbidity. Knowledge gained about how environmental risk factors impact mortality and longevity will provide insight into novel public health interventions and appropriate environmental standards to improve health and longevity. We will start analyses as soon as data are available and anticipate the project duration to be 36 months. This research will include the whole cohort.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 8615 | Metabolomic landscape of overall and common cancers in the UK Biobank: A prospective cohort study | Chanchan Hu (+5) | 2024 | International Journal of Cancer |
Enabling scientific discoveries that improve human health