| Title: | Improving causal inference in rheumatic diseases research by integrating observational and genetic epidemiology |
| Lead Institution: | University of Manchester |
| Principal investigator: | Sizheng Zhao |
Application 72723
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About
Rheumatic and musculoskeletal diseases (such as rheumatoid and osteoarthritis) are the leading causes of disability and loss of work productivity in developed countries. Their impact on individuals and societies will increase with ageing populations. Traditional research methods to identify risk factors for, and health-related consequences of, rheumatic diseases have inherent weaknesses. For example, body fat correlates with arthritis risk, but these research methods cannot tell us whether one causes the other and which way around. Untangling cause and effect is important because, for example, reducing body fat can only prevent arthritis if body fat causes arthritis, not if arthritis changes body fat. Inability to determine cause and effect is the same reason that the majority of molecules linked to arthritis do not translate into effective drug treatments. Newer scientific methods that borrow strength from genetic data can address these weaknesses and make existing research findings more relevant to public health policy and drug-development to prevent or treat rheumatic disease. We propose three objectives to address this overarching aim. We will investigate risk factors that can be modified to prevent rheumatic diseases (Aim 1) and, in reverse, whether rheumatic diseases influence risk factors or other diseases (Aim 2). We will incorporate genetic data to improve accuracy of disease definitions (Aim 3), which will help all future UK biobank studies of these diseases and is required to achieve Aims 1 and 2.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 7569 | Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization | Sizheng Steven Zhao (+7) | 2022 | Rheumatology |
| 11691 | Genetically Proxied Interleukin-13 Inhibition Is Associated With Risk of Psoriatic Disease: A Mendelian Randomization Study | Sizheng Steven Zhao (+4) | 2024 | Arthritis & Rheumatology |
| 8315 | IL-6 receptor inhibition and risk of sarcoidosis: a Mendelian randomization study | Sizheng Steven Zhao (+2) | 2023 | Rheumatology |
| 8614 | IL-6 receptor inhibition is not associated with body weight or composition: Mendelian randomisation study | Sizheng Steven Zhao | 2024 | Clinical Rheumatology |
| 11984 | Modifiable risk factors and inflammation-related proteins in polymyalgia rheumatica: genome-wide meta-analysis and Mendelian randomization | Sizheng Steven Zhao (+4) | 2024 | Rheumatology |
Enabling scientific discoveries that improve human health