| Title: | Exploring the associations between autoimmune rheumatic diseases and cardiovascular diseases. |
| Lead Institution: | Zhejiang Chinese Medical University |
| Principal investigator: | Dr Xiaohui Sun |
Application 71610
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About
Cardiovascular diseases are the top causes of death in the world. The patients with autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, were found to have a higher risk of developing cardiovascular diseases compared with the general population. However, the influence of shared genetics and biology in both diseases remain incompletely understood. This project aims to explore the potential causal relationships between autoimmune disease and cardiovascular diseases. We will perform statistical analysis to investigate the association between autoimmune diseases and cardiovascular diseases by using the large cohort data in UK Biobank. Moreover, we will examine whether autoimmune rheumatic diseases interact with other risk factors (e.g. lifestyle, dietary factors) on the development of cardiometabolic disease. To circumvent some of the limitations of conventional epidemiological analyses, we will also complement these analyses by Mendelian randomization analysis, in which genetic variants will be used instead of the described exposure variables. The purpose of this project is to better understand the association between autoimmune rheumatic diseases and cardiovascular diseases. The knowledge will provide novel insights into the identification of potential therapeutic targets for these diseases.4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9380 | Air Pollution and Allergic Rhinitis: Findings from a Prospective Cohort Study | Peiyang Luo (+8) | 2023 | Environmental Science and Technology |
| 10006 | Association between combined exposure to ambient air pollutants, genetic risk, and incident gout risk: A prospective cohort study in the UK Biobank | Wei Liu (+11) | 2024 | Seminars in Arthritis and Rheumatism |
| 9945 | Characterizing the polygenic overlap and shared loci between rheumatoid arthritis and cardiovascular diseases | Xiaohui Sun (+8) | 2024 | BMC Medicine |
| 8943 | Metabolic Syndrome Is Associated With an Increased Risk of Rheumatoid Arthritis: A Prospective Cohort Study Including 369,065 Participants | Peiyang Luo (+10) | 2024 | The Journal of Rheumatology |
Enabling scientific discoveries that improve human health