| Title: | Characterizing brain changes across the life span - a missing link to cognitive dysfunction |
| Lead Institution: | National University of Singapore |
| Principal investigator: | Dr Saima Hilal |
Application 71022
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About
Aim: It has been suggested that brain changes across the life span are strong predictors of cognitive functioning at older ages. Unfortunately, there is no data on brain damage across the life span in both Asian and European countries. We aim to find causes for cognitive dysfunction in the multi-ethnic populations from Singapore and UK and identify individuals who might be at high risk of cognitive decline and other clinical events. We will study early-aged, middle-aged, and late-life individuals by using the information on their lifestyle, blood tests, and brain MRI scan. We will then link these data with information on cognitive function. We will also study how changes in lifestyle, brain, and blood markers affect cognition over time and increase the risk of cognitive decline. Scientific rationale: we will be able to identify factors and processes that determine why some people develop cognitive impairment and others do not develop this disease. This knowledge will inform the development of strategies for health promotion, and the design of personalized interventions tailored to the individual's specific behavioral risks such as lifestyle modification. Project duration: 3 year period Public health impact: This research will identify new opportunities to improve public health policies, resulting in better interventions and management of cognitive decline at an early stage. This will enable clinicians to make earlier diagnoses, identify those at risk, and prevent the development of cognitive decline according to the risk profile in precision aging public health.3 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9026 | Association of Multi-Domain Factors with Cognition in the UK Biobank Study | W. Y. Tan (+3) | 2024 | The Journal of Prevention of Alzheimer's Disease |
| 10405 | Association of physical activity with dementia and cognitive decline in UK Biobank | Xiangyuan Huang (+3) | 2023 | Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring |
| 12988 | Incremental value of multidomain risk factors for dementia prediction: A machine learning approach | Wei Ying Tan (+7) | 2024 | American Journal of Geriatric Psychiatry |
Enabling scientific discoveries that improve human health