| Title: | Sarcopenia: prevalence, determinants and clinical outcomes |
| Lead Institution: | University of Lille |
| Principal investigator: | Professor Julien Paccou |
Application 66515
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About
Sarcopenia is a muscle disease rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age (~10%) but can also occur earlier in life. Sarcopenia is defined by low levels of measures for three parameters: (i) muscle strength, (ii) muscle quantity and (iii) physical performance as an indicator of severity. There are still many gaps in our knowledge about sarcopenia-its initiation and progression, diagnostic tools and cut-off points, and outcomes particularly in a middle-aged population of both men and women. Our purpose is to gain a better understanding of the roles of sarcopenia in aging muscles and metabolic disease in a middle-aged population of men and women, particularly its potential determinants and clinical outcomes, and ways of properly assessing it. The aims are to determine (i) the prevalence of sarcopenia using various definition in middle-aged men and women, (ii) determinants of sarcopenia (age, gender, comorbidities, physical activity...), and (iii) clinical outcomes (mortality, fractures, disability, falls, quality of life, metabolic disease such as diabetes and cardiovascular events). The project duration is expected to be 24 months and this research will promote early detection and treatment of sarcopenia in order to prevent or delay adverse outcomes that also incur a heavy burden for patients and healthcare systems.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9441 | Association Between Sarcopenia and Fracture Risk in a Population From the UK Biobank Database | Charlotte Jauffret (+5) | 2023 | Journal of Bone and Mineral Research |
| 8365 | Association between sarcopenia and risk of major adverse cardiac and cerebrovascular events-UK Biobank database | Charlotte Jauffret (+5) | 2023 | Journal of the American Geriatrics Society |
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