| Title: | Genetic contributors to complex human traits: emphasis on neurological and cardiovascular-related diseases and the interplay between these two systems |
| Lead Institution: | Montreal Heart Institute |
| Principal investigator: | Dr Sarah Gagliano Taliun |
Application 66222
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About
Project aims: We aim to identify and better understand the genetic contributors underlying human diseases in order to better predict who will develop disease and how we can more effectively treat different clinical presentations. Background/scientific rationale: Using large collections of genetic information from hundreds of thousands of individuals and comparing them to individuals that do not have disease can enable the association of disease with previously unknown genes and genomic regions. The identification of new genetic contributors can provide new targets for researchers to investigate in order to ultimately develop new treatment approaches. Our focus will be on cardiovascular-related and neurological diseases, two of the leading causes of death or disability as the population ages, as well as the interplay between these two biological systems. Anticipated project duration: 36 months Potential public health impact: As genetic data becomes more readily available in the clinic, it will be increasingly important to accurately predict disease risk to more accurately treat and follow patients that are predisposed for disease. By identifying new genes and biological mechanisms involved in disease onset or progression, this project has the potential to provide novel avenues for advancing knowledge on cardiovascular-related and neurological diseases, and to open up previously undiscovered treatment possibilities.4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 13078 | Association of Genetically Predicted Skipping of COL4A4 Exon 27 with Hematuria and Albuminuria. | Frida Lona-Durazo (+12) | 2024 | Journal of the American Society of Nephrology |
| 11127 | Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes | Muhammad Shoaib (+7) | 2023 | Genetic Epidemiology |
| 9339 | GWAS for the composite traits of hematuria and albuminuria | Sarah A. Gagliano Taliun (+5) | 2023 | Scientific Reports |
| 10172 | Genetically predicted waist-to-hip circumference ratio and coronary artery disease: A sex-specific Mendelian randomization study | Qiang Ye (+1) | 2023 | Human Genetics and Genomics Advances |
Enabling scientific discoveries that improve human health