| Title: | Genetic and Biomarker Data Improve Risk Prediction for Gastrointestinal Cancer in large Population Studies |
| Lead Institution: | Fudan University |
| Principal investigator: | Dr Chen Suo |
Application 63726
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About
Aims we aim to evaluate the performance of these indices in the prediction of cancer risk and to construct a predicting score mechanism based on the large cohort study. The background and scientific rationale of the proposed research project in general. How to early diagnosis cancer in population is key to disease prevention and control, which means a sensitive screening method should be used to public health career. Previous studies have reported that Mendelian disorders and monogenic traits result from combinations of variants in 1 or a few genes that have a large effect on the propensity for developing a certain disease or characteristic. However, the practical applications of polygenic risk information for screening or for guiding lifestyle and medical interventions in the clinical setting remain further analysis. Project duration 24 months Public health impact Our study is informative to identify individuals at high risk of premature death and help personalize preventive measures. Our results are of importance arrangement of limited medical resources and management of large population.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 10625 | Alcohol consumption and hepatocellular carcinoma: novel insights from a prospective cohort study and nonlinear Mendelian randomization analysis | Zhenqiu Liu (+6) | 2022 | BMC Medicine |
| 11268 | Characteristics and long-term mortality of patients with non-MAFLD hepatic steatosis | Hong Fan (+8) | 2023 | Hepatology International |
| 7455 | Genetic predisposition, lifestyle risk, and obesity associate with the progression of nonalcoholic fatty liver disease | Zhenqiu Liu (+6) | 2021 | Digestive and Liver Disease |
| 12610 | Phenome-Wide Association Analysis Reveals Novel Links Between Genetically Determined Levels of Liver Enzymes and Disease Phenotypes | Zhenqiu Liu (+6) | 2022 | Phenomics |
| 13045 | Point-based risk score for the risk stratification and prediction of hepatocellular carcinoma: a population-based random survival forest modeling study | Zhenqiu Liu (+7) | 2024 | EClinicalMedicine |
Enabling scientific discoveries that improve human health