| Title: | Understanding the inherited and acquired genetic changes that influence blood cancer risk. |
| Lead Institution: | University of Cambridge |
| Principal investigator: | Dr Jamie Blundell |
Application 58387
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About
As individuals age the cells that make up their tissues acquire genetic mutations. If these mutations impact certain genomic regions they can increase the risk of cancer. The central aim of this project is to study how acquired mutations impact blood cancer risk by using data from UKBiobank to identify individuals who have acquired mutations in their blood. Linking this data with known cancer status of participants we will better understand how these acquired mutation increase peoples risk of developing a blood cancer. We will integrate information on single-nucleotide variants in known blood-cancer associated genes ('clonal haematopoiesis') with data on known mosaic chromosomal alterations (mCAs) to build more complete picture of which acquired mutations arise in people as part of the normal ageing process and which acquired mutations confer a substantially increased risk of developing a future cancer. We expect this project to take 3 years at the end of which we aim to be able to more accurately predict the risk of blood cancer from genomic data acquired from sample of peripheral blood.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9592 | Mutation rates and fitness consequences of mosaic chromosomal alterations in blood | Caroline J. Watson (+1) | 2023 | Nature Genetics |
Enabling scientific discoveries that improve human health