| Title: | Stratification of health outcomes in mood disorders |
| Lead Institution: | Scientific Institute Ospedale San Raffaele |
| Principal investigator: | Dr Chiara Fabbri |
Application 56514
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About
Mood disorders are a major burden to individuals and society, representing the second-leading cause of disability in young people. Suicide is not the only unfavorable outcome of these disorders, but chronic and intermittent courses associated with functional impairment and deterioration of physical health are common. Disease course, response to treatments and development of psychiatric and medical comorbidities are currently largely unpredictable, particularly in the first phase of the disease when there would be more chances of intervention and prevention. This project will aim to contribute in filling this gap in knowledge by identifying clinically meaningful groups of mood disorders having specific characteristics in terms of health-related outcomes, such measures of functioning and well-being, response to treatments and risk of comorbid psychiatric and medical disorders. Replication of results in independent samples will be a fundamental step of this research. Possible clinical interventions targeted on specific patients' groups will be evaluated, such as screening for co-morbid disorders and educational programs for prevention or management of mental health disorders. The findings of our research will inform public health policy aimed at promoting prevention and treatment of mood disorders.3 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 7236 | Depressive symptoms and neuroticism-related traits are the main factors associated with wellbeing independent of the history of lifetime depression in the UK Biobank | Chiara Fabbri (+3) | 2021 | Psychological Medicine |
| 8722 | Polygenic risk scores for mood and related disorders and environmental factors: Interaction effects on wellbeing in the UK biobank | Chiara Fabbri (+2) | 2024 | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| 9590 | The Effects of CYP2C19 Genotype on Proxies of SSRI Antidepressant Response in the UK Biobank | Win Lee Edwin Wong (+7) | 2023 | Pharmaceuticals |
Enabling scientific discoveries that improve human health