| Title: | An Integrated Exploration of Behavioral, Environmental, and Genetic Predictors Associated with the Onset and Prognosis of Cardiovascular Disease, Digestive Diseases, and Multimorbidity |
| Lead Institution: | Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University |
| Principal investigator: |
Application 564547
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About
Modifiable and genetic determinants could jointly influence the onset and development of cardiovascular and digestive diseases, as well as multimorbidity. However, research in this domain remains nascent. We aim to: (1) identify modifiable risk factors and unrecognized biomarkers to elucidate their direct effects and potential moderating functions on gastro-cardiovascular disorders and co-morbidities; (2) infer potential causal associations between different variables and gastro-cardiovascular disorders and co-morbidities; (3) unravel genetic variants and candidate genes associated with higher disease susceptibility, and the level of proteins, metabolites and gene expression; (4) discover potential genetic correlations between gastro-cardiovascular disorders and co-morbidities; (5) provide mechanistic insight into how candidate genes exert their effects on disease development; (6) identify potential molecular targets for drug repurposing. (7) construct robust prognostic algorithms to predict the probability of disease onset, disease progression, life expectancy and incidence of other health-related endpoints for the early detection of high-risk populations. Scientific rationale: Prospective cohorts yield extensive data for disease analysis and prevention. Genomic studies pinpoint disease-associated genetic variants and genes. Statistical and machine learning models enable risk factor screening, mediation analysis, effect size estimation, causal inference, and personal risk scoring. Single-cell RNA-seq integration reveals gene roles in disease pathology, informing modeling and drug targets. Transcriptome-wide association study elucidates gene expression regulation in diseases.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 19790 | Visceral Adiposity Index and the Development of Abdominal Aortic Aneurysm: A Retrospective Cohort Study of Sex Differences and Genetic Susceptibility in the UK Biobank | Xiangpeng Zeng (+5) | 2026 | European Journal of Vascular and Endovascular Surgery |
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