| Title: | Investigation of Lifestyle, Environmental, and Clinical Determinants on Urological Cancer and Nephrology-related Diseases |
| Lead Institution: | Nanchang University |
| Principal investigator: |
Application 532564
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About
Objective: To investigate the lifestyle, environmental, and clinical determinants that influence the onset and progression of urological cancer (e.g., renal cell carcinoma, bladder cancer) and nephrology-related diseases, and to understand how these factors interact with each other. Data Source: Utilize comprehensive datasets from the UK Biobank, including information on participants' lifestyle factors, environmental exposures, clinical history, imaging data, and biomarker profiles. Methodology: Epidemiological Analysis: Assess the associations between lifestyle factors (e.g., physical activity, diet), environmental exposures (e.g., pollution, occupational hazards), and clinical indicators (e.g., blood pressure, renal function) with disease risk. Statistical Modeling: Employ advanced statistical techniques and machine learning algorithms to identify significant predictors and interactions among the determinants. Biomarker Evaluation: Analyze blood and imaging biomarkers to identify potential early indicators of disease progression and prioritize therapeutic targets. Expected Outcomes: Identification of key risk factors contributing to urological cancer and nephrology-related diseases. Understanding of the interplay between lifestyle, environmental, and clinical factors in influencing disease progression. Development of evidence-based strategies for early detection, prevention, and personalized therapeutic approaches. Impact: The findings will guide the design of targeted interventions and inform public health strategies, ultimately aiming to reduce the incidence and improve the management of these diseases.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 18013 | Association between physical activity patterns and renal cell carcinoma risk: evidence from the UK biobank large-scale prospective cohort | Fuchun Zheng (+7) | 2026 | Scientific Reports |
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