| Title: | Genetic, environmental and clinical determinants of blood pressure, kidney health and disease. |
| Lead Institution: | University of Manchester |
| Principal investigator: | Professor Maciej Tomaszewski |
Application 46114
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About
High blood pressure and kidney disease are the main threats to human health and the key contributors to premature death. The predisposition to the development of both high blood pressure and kidney disease is partly determined at birth (through DNA inherited from both parents) and partly through the lifestyle and environmental factors. However, the precise mechanisms of their interactions in relation to high blood pressure and kidney disease are not clear. Our objective is to characterise these interactions, gain new insights into the biology of both diseases and to build up new predictive models of high blood pressure and kidney disease. We will utilise genetic information derived from Axiom array and exome sequencing, data on environmental exposure and lifestyle choices and various dimensions of the collected clinical information in relation to blood pressure and measures of kidney health. We intend to start our analysis in April 2019 and we anticipate it will take up to 3 years. This project will provide the explanation for why people show significant differences in blood pressure and kidney health and why certain individuals are more susceptible to high blood pressure and kidney disease. This in turn will improve our understanding of cardiovascular and renal system with a potential for improved treatment of hypertension and chronic kidney disease.3 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 7235 | Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics | Xiaoguang Xu (+12) | 2021 | Cardiovascular Research |
| 10090 | Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets | Xiaoguang Xu (+37) | 2024 | Nature Communications |
| 12847 | Whole -genome survival analysis of 144 286 people from the UK Biobank identifies novel loci associated with blood pressure | Sushant Saluja (+4) | 2024 | Journal of Hypertension |
Enabling scientific discoveries that improve human health