| Title: | Survey of Genetic Factors Affecting Disease Risk and Progression. |
| Lead Institution: | Genentech, Inc. |
| Principal investigator: | Rion Pendergrass |
Application 44257
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About
This project aims to study how a person's genes affects the risk and progression of a broad range of diseases and medical conditions including cancer, immunology, neuroscience, ocular and metabolism.Through the understanding of genetic variants associated with disease risk and progression, we can identify new targets for drug development that will eventually lead to new treatments being available for these diseases. In addition, we will also develop ways to better identify and categorize a person's disease so that we may decide which drug might be the most effective for their treatment or identify those who would most benefit from developing new drugs. We envision this as a multi year project as new data becomes available and investigation methodologies will change. In addition, as new methods are developed, they may be reapplied to this project and this project may possibly combine its data with future datasets to create combined datasets that are more effective at revealing how genes affect diseases.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 11678 | Blood protein assessment of leading incident diseases and mortality in the UK Biobank | Danni A. Gadd (+13) | 2024 | Nature Aging |
| 13086 | Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK Biobank | Robert F. Hillary (+10) | 2024 | Nature Communications |
Enabling scientific discoveries that improve human health