| Title: | Discovery and characterization of the genetic contribution to kidney function |
| Lead Institution: | University of North Carolina at Chapel Hill |
| Principal investigator: | Dr Nora Franceschini |
Application 42633
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About
Chronic kidney disease (CKD) is an important public health problem, affecting 10% of people worldwide, and associated with premature cardiovascular disease and death. Little is known on its causes and there is no effective treatment. This proposal aims to identify genetic risk factors for CKD and its associated metabolic changes, so to understand its causes and relationship with heart disease, and to provide new drug therapy for this condition. Our primary analyses will focus on white British individuals. We will implement genome-wide association models, while accounting for other risk factors including diabetes and hypertension. We will also evaluate the evidence of association for genetic variants identified for kidney function on cardiometabolic risk factors using biomarkers such as serum glucose, lipids, and inflammatory markers. This research may help to identify individuals at risk to be targeted in prevention programs.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9132 | Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas | Odessica Hughes (+73) | 2023 | Cell Genomics |
Enabling scientific discoveries that improve human health