| Title: | Statistical genetics methods for complex traits using large-scale genomic data |
| Lead Institution: | Hangzhou Medical College |
| Principal investigator: | Dr Guo-Bo Chen |
Application 41376
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About
Many human traits (such as height) and complex disease (such as Crohn's disease) are complex traits, which are known to be controlled by many genes of small effects. To reveal the how genes control the complex traits require large sample size, such as promised by UK Biobank. AIMs: the study is to develop statistical methods that are able to quantity how phenotypic variation is associated to genotypes. Using UK Biobank cohort as demonstration, we can provide an atlas of the heritability for a range of human complex traits and reveal the genetic architecture for complex traits. Scientific rationale: large sample size is important for scientific discovery, especially for human complex traits and diseases. However, the current statistical methods have been designed to handle small sample size, and computationally infeasible for emerging cohort such as UK Biobank. We propose a method that has its computational cost proportional to the square of the sample size. So, it will be able to handle UK Biobank data more efficiently and bring about comprehensive results than ever before. Project duration: so far we have already developed the statistical algorithm of the statistical method. It takes 1 year to realize and test the method in compute codes. Another 1 year is required to analyze the UK Biobank data thoroughly. The third year will be spent in write a report for our discovery. Public health impact: the final product of the study will be a comprehensive atlas of the quantified relationship between complex traits, a map that will shed light on the genetic architecture of complex traits and provide guidelines on mining etiology of various human complex traits and diseases.6 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 10539 | Both indirect maternal and direct fetal genetic effects reflect the observational relationship between higher birth weight and lower adult bone mass | Jiang-Wei Xia (+14) | 2022 | BMC Medicine |
| 7416 | General and abdominal obesity operate differently as influencing factors of fracture risk in old adults | Xiao-Wei Zhu (+11) | 2022 | iScience |
| 9001 | Genetic determinants of IgG antibody response to COVID-19 vaccination | Shengzhe Bian (+12) | 2024 | American Journal of Human Genetics |
| 10845 | Morroniside ameliorates inflammatory skeletal muscle atrophy via inhibiting canonical and non-canonical NF-κB and regulating protein synthesis/degradation | Xiangjiao Yi (+9) | 2022 | Frontiers in Pharmacology |
| 10741 | Observational and genetic evidence highlight the association of human sleep behaviors with the incidence of fracture | Yu Qian (+8) | 2021 | Communications Biology |
| 8961 | Searching across-cohort relatives in 54,092 GWAS samples via encrypted genotype regression | Qi-Xin Zhang (+24) | 2024 | PLOS Genetics |
Enabling scientific discoveries that improve human health