| Title: | Associations of genetics, lifestyles, and environmental risk factors with age-related diseases and aging |
| Lead Institution: | North China University of Science and Technology |
| Principal investigator: |
Application 362917
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
This research project aims to investigate the effect of genetics, lifestyles (diet, smoking, and physical activities, etc.), and environmental (non-genetic/modifiable) risk factors on age-related diseases (hypertension, diabetes, cancers, Alzheimer's disease, Parkinson's disease, osteoporosis, kidney failure, chronic obstructive pulmonary disease, multiple sclerosis, amyotrophic lateral sclerosis, cognitive function, and mental health, etc.), mortality, life expectancy, and aging. Furthermore, this project also aims to explore the interaction and joint associations of genetics, lifestyles, and environmental determinants with age-related outcomes. The aging of the global population is accelerating due to longer life expectancy. Age-related diseases refer to medical conditions that occur with advancing age, including hypertension, diabetes, cancers, Alzheimer's disease, Parkinson's disease, osteoporosis, kidney failure, chronic obstructive pulmonary disease, multiple sclerosis, and amyotrophic lateral sclerosis. These diseases remain the leading causes of death in the global elderly population. The administration of age-related diseases requires advanced medical services and long-term healthcare support. Studies indicate that extending a healthy lifespan by one year holds the possibility to decrease approximately £2,000 annually in health-related costs. The development of age-related outcomes is determined by numerous factors, including but not limited to genetics, lifestyles, and environmental risk factors. Healthier lifestyles, including stopping smoking, increasing physical activity, and maintaining a balanced diet, have been widely recognized as crucial factors in alleviating the impact of age-related disease. In light of the growing availability of genetic research, accumulating evidence highlights the contribution of genetics to the variation in age-related diseases and aging. Research has also shown that the genetic and environmental risk factors can contribute to age-related diseases and influence the aging process. However, the exact impact of these factors and the biological mechanisms underlying the progression of these outcomes remain unexplored. Collectively, it is indispensable to understand the interaction and joint associations of genetics, lifestyles, and environmental risk factors with age-related diseases, mortality, life expectancy, and aging. The study is expected to last approximately 36 months. Current research results would be utilized to optimize healthcare resource allocation, formulate precise public health strategies, and reduce the burden of age-related diseases and aging.2 Publications
Enabling scientific discoveries that improve human health