| Title: | Exploring the Association of Sex Hormone-Binding Globulin with NAFLD Risk across BMI Subgroups |
| Lead Institution: | Southern Medical University |
| Principal investigator: |
Application 283713
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About
Aims of the Study Our study aims to understand how a protein called sex hormone-binding globulin (SHBG) affects the risk of a liver disease called non-alcoholic fatty liver disease (NAFLD). NAFLD is becoming increasingly common and can lead to serious health problems. We want to see if SHBG levels, along with body mass index (BMI), can predict who is more likely to develop NAFLD. Scientific Rationale Previous studies have shown that SHBG and BMI are linked to NAFLD, but the exact relationship is not fully understood. By using data from the UK Biobank, a large national study, we can explore this relationship in more detail. We hope to find new ways to predict and prevent NAFLD, which could lead to better health outcomes for many people. Project Duration The study is expected to last several years, as we need to analyze a large amount of data and conduct statistical tests to ensure our findings are accurate. Public Health Impact If we find that SHBG and BMI are strong predictors of NAFLD risk, this could have a significant impact on public health. Doctors and health professionals could use this information to identify people at higher risk and provide them with early interventions or lifestyle advice to reduce their chances of developing NAFLD. This could lead to fewer cases of NAFLD and improved health outcomes for many people. Additionally, our findings could contribute to the development of new screening tools or therapeutic strategies to combat NAFLD, further enhancing public health efforts.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 20093 | Breastfeeding in infancy confers sex-specific, long-term protection against metabolic dysfunction-associated steatohepatitis and adverse liver outcomes | Huiyi Chen (+11) | 2026 | Biology of Sex Differences |
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