| Title: | Genetic basis of inflammatory immune mediated diseases |
| Lead Institution: | Institute of Parasitology and Biomedicine Lopez-Neyra |
| Principal investigator: |
Application 276785
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About
Immune-mediated inflammatory diseases (IMIDs) present systemic symptoms, long-term inflammation and high heterogeneity in their presentation. Because of this, IMIDs are difficult to treat and diagnose, with patients rarely being diagnosed in the early stages of these diseases. Although genetic approaches have yielded important results in the field, there is still much we do not know about these conditions. Our project aims to better characterize the genetic component of these diseases to understand the processes involved in the development of IMIDs. Understanding which pathways and genes are affected in these conditions is highly relevant because genetic predictors can lead to better diagnosis and prevention strategies, and also propose new treatments for these diseases. Genome-wide association analysis is a well-established approach to advance the basic knowledge of complex diseases, because it allows the study of genetic variants through the entire genome, comprehensively testing all genes that could be associated with these conditions. We aim to deepen this approach by also performing cross-diseases genomic analysis to study shared pathways between conditions. This would give us a more comprehensive perspective of the shared components between IMIDs.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 19856 | Novel HLA class I and II insights into the pathogenesis of systemic sclerosis-associated interstitial lung disease | Carlos Rosa-Baez (+24) | 2026 | Annals of the Rheumatic Diseases |
| 20217 | Novel pleiotropic loci link vascular and immune pathways in systemic sclerosis and primary Raynaud's phenomenon | Carlos Rangel-Peláez (+153) | 2026 | Rheumatology |
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