| Title: | Genetic Determinants of Bone Mineral Density and Fractures |
| Lead Institution: | Jewish General Hospital |
| Principal investigator: | Dr Brent Richards |
Application 24268
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About
We aim to identify genetic determinants of bone mineral density and fractures. Fractures are a common and costly medical problem, which are partially heritable. Understanding the genetic determinants of fracture will help us to understand what causes fracture. Our project meets the UK Biobank?s aim of improving the prevention, diagnosis and treatment of serious and life threatening illnesses. The proposed study aims to better understand the pathophysiologic mechanisms which lead to fracture, by determining the genetic variants that predispose to fracture and low bone mineral density. Low bone mineral density is a clinically useful predictor of fracture and most of the genetic determinants for fracture identified to date also influence bone density. We propose to undertake a genome-wide association study of individuals in the UKBiobank who have had heel bone density measured, as well as, a genome-wide association study of fracture, using as cases individuals who have reported a bone fracture within the past five years and control individuals who have not reported a bone fracture within the past five years. Briefly, we will undertake an additive allelic association test between each single nucleotide polymorphism and these two traits (bone density and fracture) We request the full cohort.3 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 8680 | An atlas of genetic influences on osteoporosis in humans and mice | John A. Morris (+58) | 2018 | Nature Genetics |
| 10343 | Identifying Causes of Fracture Beyond Bone Mineral Density: Evidence From Human Genetics | Tianyuan Lu (+3) | 2022 | Journal of Bone and Mineral Research |
| 11076 | Increasing serum iron levels and their role in the risk of infectious diseases: a Mendelian randomization approach | Guillaume Butler-Laporte (+9) | 2023 | International Journal of Epidemiology |
Enabling scientific discoveries that improve human health