| Title: | How can physical activity and fitness improve brain health in people with serious mental illness? |
| Lead Institution: | University of Manchester |
| Principal investigator: | Dr Joseph Firth |
Application 22125
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About
The aim of this research is to explore how different types of physical activity and exercise are associated with brain structure, connectivity, and functioning in people with serious mental disorders (including schizophrenia and related psychotic disorders, major depression and / or bipolar disorder). This will help to determine the optimal frequency, intensity and modalities of exercise interventions for improving functional outcomes in people with mental illness. Serious mental illness (SMI) is associated with various neurocognitive impairments, which are predictive of poor social and occupational functioning. Research in healthy samples has shown physical activity can improve various aspects of neurocognition. However, the optimal types of activity and exercise for improving cognition in SMI has yet to be established. This research will determine what frequencies, modalities and intensities of exercise are most associated with greater cognitive functioning among people with SMI, to inform future physical activity interventions for improving their neurocognition and quality of life. Physical exercise has been shown to improve neurocognition in the general population. In this project, we will use self-reported physical activity, accelerometry and cardiorespiratory fitness data from people with SMI, in order to examine how different types and intensities of exercise are correlated with brain structure and functioning. Full cohort2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 7346 | Grip Strength Is Associated With Cognitive Performance in Schizophrenia and the General Population: A UK Biobank Study of 476559 Participants | Joseph Firth (+9) | 2018 | Schizophrenia Bulletin |
| 12908 | Handgrip Strength Is Associated With Hippocampal Volume and White Matter Hyperintensities in Major Depression and Healthy Controls: A UK Biobank Study. | Josh A Firth (+9) | 2019 | Psychosomatic Medicine |
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