| Title: | Lifestyle factors, body fat deposition in different compartments and risk of pancreatic cancer. |
| Lead Institution: | Sun Yat-sen Memorial Hospital, Sun Yat-sen University |
| Principal investigator: |
Application 184441
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About
Pancreatic cancer has a poor prognosis and is believed to develop due to a complex interplay of lifestyle and genetic factors. Identifying the variable lifestyle risk factors is important for preventing pancreatic cancer. Obesity is one of the mutable risk factors. The strong link between visceral fat and metabolism suggests that the increased fat in different body parts plays an important role in increasing the risk of pancreatic cancer, similar to overall obesity. Non-invasive technologies such as MRI and DXA allow us to visualize the distribution of body fat. Increased fat in the pancreas is thought to promote inflammation and releases some harmful adipokines that can elevate the risk of pancreatic diseases. Many of the same lifestyle risk factors for increased body fat and pancreatic cancer have been observed in clinical studies. It suggests that increased body fat may play a mediating role in the elevated risk of pancreatic cancer due to lifestyle risk factors. We intend to identify lifestyle factors associated with pancreatic cancer and body fat deposition in different compartments such as visceral, subcutaneous, liver and pancreas. We also seek to investigate the relationship between different body fat distribution patterns and the risk of pancreatic cancer, and the mediating role of body fat deposition in the development of pancreatic cancer contributed by lifestyle risk factors. The project is expected to take 36 months to complete. It helps to explore whether body fat fraction in different compartments can serve as an indicator on the control of lifestyle risk factors related to pancreatic cancer and determining the appropriate control range. It can provide insights into the reversible risk factors of pancreatic cancer, provide a research direction for the pathogenesis of pancreatic cancer and assist in the prevention and screening of pancreatic cancer in the population.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 17950 | The mediating role of biological age acceleration in the associations between lifestyle factors and incident digestive system cancers: A Prospective Cohort Study from the UK Biobank | Wei Huang (+6) | 2026 | The journal of nutrition health & aging |
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