| Title: | Toward precision medicine in the comorbidity of epilepsy and headaches based on multimodal imaging genomics analysis |
| Lead Institution: | Wuhan University |
| Principal investigator: |
Application 143136
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About
Headaches and epilepsy are among the most frequently encountered nervous system diseases. A large number of studies have highlighted the complex relationship between headaches and epilepsy. Evidence has shown that up to 79% of individuals with epilepsy reported experiencing headaches. Patients with epilepsy have a 52% greater lifetime prevalence of migraines than those without epilepsy. Also, the estimated prevalence of unspecified headache was 49% among people with epilepsy. However, the underlying mechanism of the co-morbidity of epilepsy and headaches remains unclear. Using the UK Biobank database, this study aims to integrate clinical data, psychosocial factors, neuroimaging, and genetic data of the co-morbidity of epilepsy and headaches, and use large sample data to explore precise objective biomarkers related to the co-morbidity of epilepsy and headaches. Combining multiple computer methods such as machine learning and deep learning, and integrating genetic, brain imaging and cognitive/emotional data, and demographic data from the UK Biobank, the onset of the co-morbidity of epilepsy and headaches is predicted through cross-sectional and prospective follow-up data. We will examine associations between genes, brain imaging and cognitive/mood data, demographic data, and explore how these associations are mediated by brain MRI or mediated by biomarker variables (inflammatory markers, vitamins, etc.) of. It is expected to screen out 2-3 accurate, sensitive and effective monitoring biomarkers for the co-morbidity of epilepsy and headaches, and build a prevention and treatment network for the co-morbidity of epilepsy and headaches research. Provide active and effective scientific and technological support for accelerating technological breakthroughs in the prevention and control of the co-morbidity of epilepsy and headaches, controlling the growth of medical expenses, promoting the rational and standardized application of technology, reducing medical and social burdens, and curbing the high incidence and mortality of the co-morbidity of epilepsy and headaches.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 12057 | Poor healthy lifestyle and life's essential 8 are associated with higher risk of new-onset migraine: a prospective cohort study | Yuexiu Lei (+7) | 2024 | The Journal of Headache and Pain |
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