| Title: | Drivers and Consequences of Immunosenescence and Inflammaging in Humans |
| Lead Institution: | Leibniz Institute on Aging (Fritz Lipmann Institute) |
| Principal investigator: |
Application 129228
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About
With the rising life expectancy across the globe, it is crucial to understand how our bodies change with age and how we may counteract the negative effects. Notably, even "healthy" older individuals exhibit low levels of inflammation in their bodies. The origin and consequences of such low-grade inflammation are not well characterized. Using extensive health data from the UK Biobank, we plan to: - Develop a way to measure immune aging, or an 'immune clock,' by analyzing blood samples for signs of immune health. - Look at how differences in this 'immune clock' relate to various health conditions in older adults to understand its importance. - Identify specific genes and biological pathways that could explain why some people's immune systems age faster than others. - Use advanced statistical methods to study whether inflammaging contributes to or results from age-related health issues. - Investigate if the leaking of microbes from different body sites, such as the gut, into the bloodstream contributes to inflammaging. Our research could lead to a better understanding of the immune aging and how it's linked to chronic diseases, potentially guiding new treatments to improve the health of the aging population. This work holds promise for identifying new targets aimed at improving healthspan and reducing the burden of age-related conditions. The duration of this research project is 3 years.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 17946 | Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging | Tetiana Poliezhaieva (+12) | 2026 | Nature Communications |
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