| Title: | Investigating biological mechanisms and prediction of immune-mediated postoperative complications |
| Lead Institution: | University of Bristol |
| Principal investigator: |
Application 128619
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
Background and rationale One in 7 patients develop a serious medical problem after surgery which can affect a broad range of organ systems including the brain, heart, kidneys and others. The reasons these complications happen are poorly understood. Our knowledge of which patients are more likely to develop these complications is limited, and currently does not make use of detailed information we can collect on patients, for example their unique genetic make-up and biochemical analysis. Aims 1. I will try to predict which patients are at most risk of surgical complications using genetic and health information from a large UK population-based study (UK Biobank). 2. I will test whether inflammation (activation of our immune system) after surgery could be an underlying cause of these complications using genetic methods. I will also use clinical measurements to explore how different body systems react after surgery.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 17544 | The genetic architecture of postoperative delirium after major surgery and its relationship with nonpostoperative neurocognitive conditions: A genome-wide association study | Richard A. Armstrong (+4) | 2026 | PLOS Medicine |
Enabling scientific discoveries that improve human health