| Title: | ETHNIC VARIATIONS IN LONG-TERM HEALTH OUTCOMES AND MORTALITY BETWEEN MINORITY ETHNICS AND WHITE EUROPEANS LIVING IN THE WEST |
| Lead Institution: | University of Warwick |
| Principal investigator: |
Application 103665
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About
The project will aim to investigate and quantify the relationship between ethnicity, cardiovascular disease in the United Kingdom, comparing the performance of ethnic minorities and the local white ethnicity in cardiovascular disease(CVD)-related health outcomes. The UK has a large migrant population (around 17% UK residents born outside the UK) and health inequalities manifest themselves when one compares the outcomes of diseases and adverse health conditions between the migrants and non-migrants. The outcomes include disease-related death, ability to complete basic physical tasks, mental health, social circle, financial worries. Cardiovascular diseases, conditions which affect the heart or blood vessels, are the leading cause of premature death worldwide. It affects around 7 million people (over 10% of total population) and is responsible for 1 in 4 premature deaths in the UK. Many risk factors of CVD are modifiable, for example inactivity and poor diet increase the risk of CVD. People can mitigate these risks by becoming more active and improving their diets. However other factors are not modifiable, such as ethnicity; black Asian, minority ethnic (BAME) people are at a higher risk of CVD. This project follows a framework which attempts to answer the following questions: (1) Is there a relationship between ethnicity and CVD-related mortality? (2) If yes, what factors have a moderating effect on the relationship between ethnicity and CVD and quality of life (QOL)? (3) Does this differ when comparing the ethnic minority people to the local people of that ethnicity (for example comparing British Indians to Indians)? (4) Did the COVID-19 pandemic play a role in the QOL of those who developed CVD during the pandemic? (5) Are polygenic risk scores (PGS), which are an estimate of someone's genetic liability to a certain disease or trait, significantly associated to ethnicity, CVD, and QOL? This project will help public policy in knowing what behavioural factors should be focused on, and if someone has a high heritability to CVD, knowing the steps to be taken to minimise the risk. This project may also raise more questions and potential hypotheses which should be explored further down the line. We anticipate this project which uses the genetic data to take approximately one year and will make up the final piece of a larger PhD project exploring CVD-related health outcomes in ethnic minorities in the UK.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 13245 | Ethnic-Specific Threshold Analysis and BMI and Waist Circumference Cutoffs for Cardiovascular Disease and Subjective Wellbeing: Results using Data from the UK Biobank | Mubarak Patel (+2) | 2024 | Journal of Racial and Ethnic Health Disparities |
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