| Title: | Epidemiologic and genetic risk factors for benign and malignant pancreatic diseases |
| Lead Institution: | Third Xiangya Hospital of Central South University |
| Principal investigator: |
Application 103631
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About
Pancreatic diseases are one of the most frequent gastrointestinal causes of hospitalization worldwide and remain a substantial burden especially in developed countries. The high lethality of pancreatic cancer (PC) and the serious burden of pancreatitis has become a dilemma to tackle globally. It is urgent to develop early risk prediction and effective prevention for both PC and pancreatitis. It has been gradually recognized that complicated mechanisms driven by genetic, environmental, dietary, and lifestyle factors are involved in the initiation and progression of pancreatic diseases. To systematically investigate the risk factors of PC and pancreatitis, we will complete this project within 36 months after data totally available. The specific aims include 1) To fill in gaps in knowledge about factors related to the causes and outcomes of pancreatic diseases; 2) To better understand the molecular epidemiology of pancreatic diseases by investigating biomarkers and genetic factors; 3) To develop and validate risk prediction and prognostic models. By comprehensively investigating the possible risk factors, our project would not only benefit population prevention, screening, and treatment but also assist to develop better management for pancreatic diseases.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 11733 | 24-Hour Urinary Sodium Excretion Is Associated With Increased Risk of Pancreatic Cancer: A Prospective Cohort Study. | Jiayi Wang (+5) | 2024 | Clinical and Translational Gastroenterology |
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