| Title: | Explore the factors associated with chronic diseases and their biomarkers |
| Lead Institution: | Jilin University |
| Principal investigator: |
Application 1011696
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About
Research Questions: This study focuses on chronic diseases, including cardiovascular disease, diabetes and cancer, as well as other serious conditions. How do modifiable lifestyle factors and non-modifiable factors interact across the life course to collectively influence the onset, progression, treatment, and prognosis of chronic diseases? What is the utility of novel multi-omics biomarkers in enhancing the early detection and progression prediction of chronic diseases, and can related interventions be developed to prevent and manage these conditions? How can relevant risk factors and biomarkers be integrated to improve the prediction of chronic disease outcomes and enhance strategies for their prevention and management? Research Objectives: To quantify the impact of relevant risk factors on the incidence and progression of chronic diseases. To discover and validate the predictive power of relevant risk factors and biomarkers, along with their associative or causal links with diseases, thereby laying the groundwork for novel insights and perspectives on chronic disease prevention and management. Scientific Rationale: Chronic diseases necessitate a strategic shift from treatment-focused approaches to proactive prevention. While certain risk factors are established, their cumulative and interactive effects on disease pathogenesis remain insufficiently quantified. Concurrently, advances in high-throughput omics technologies provide unprecedented opportunities to discover and characterize biomarkers associated with chronic diseases. This research is grounded in the hypothesis that integrating comprehensive risk factor profiles with multidimensional biomarker data will yield a more holistic understanding of disease mechanisms, enabling a more effective and comprehensive strategy for chronic disease prevention and control. We will disseminate our research findings through academic papers, conference reports, and website development.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 20146 | Plasma proteomic profiles reveal proteins and characteristic patterns associated with hypertension: A prospective cohort study | Hongrui Zhang (+14) | 2026 | Journal of Hypertension |
Enabling scientific discoveries that improve human health