| Title: | Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent |
| Journal: | Nature Communications |
| Published: | 18 Dec 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31852892/ |
| DOI: | https://doi.org/10.1038/s41467-019-13544-0 |
| URL: | https://kclpure.kcl.ac.uk/ws/files/123433467/Genetic_correlations_of_psychiatric_HUEBEL_Acc11Sep2019Epub18Dec2019_GOLD_VoR_CC_BY_.pdf |
| Citations: | 67 (15 in last 2 years) as of 8 Aug 2024 |
Publication 9088
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Abstract
Body composition is often altered in psychiatric disorders. Using genome-wide common genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat mass, fat-free mass, physical activity, glycemic traits and 17 psychiatric traits (up to N = 217,568). Two patterns emerge: (1) anorexia nervosa, schizophrenia, obsessive-compulsive disorder, and education years are negatively genetically correlated with body fat % and fat-free mass, whereas (2) attention-deficit/hyperactivity disorder (ADHD), alcohol dependence, insomnia, and heavy smoking are positively correlated. Anorexia nervosa shows a stronger genetic correlation with body fat % in females, whereas education years is more strongly correlated with fat mass in males. Education years and ADHD show genetic overlap with childhood obesity. Mendelian randomization identifies schizophrenia, anorexia nervosa, and higher education as causal for decreased fat mass, with higher body fat % possibly being a causal risk factor for ADHD and heavy smoking. These results suggest new possibilities for targeted preventive strategies.</p>
18 Keywords
- Age Factors
- Blood Glucose
- Body Composition
- Comorbidity
- Educational Status
- Female
- Genetic Variation
- Genome-Wide Association Study
- Humans
- Male
- Mental Disorders
- Middle Aged
- Multifactorial Inheritance
- Overweight
- Phenotype
- Physical Fitness
- Risk Factors
- Sex Factors
12 Authors
- Christopher Hübel
- Héléna A. Gaspar
- Jonathan R. I. Coleman
- Ken B. Hanscombe
- Kirstin Purves
- Inga Prokopenko
- Mariaelisa Graff
- Julius S. Ngwa
- Tsegaselassie Workalemahu
- Paul F. O'Reilly
- Cynthia M. Bulik
- Gerome Breen
1 Application
| Application ID | Title |
|---|---|
| 27546 | Metabolic and psychiatric genetics of eating disorders, BMI and obesity |
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