| Title: | Metabolic and psychiatric genetics of eating disorders, BMI and obesity |
| Lead Institution: | King's College London |
| Principal investigator: | Dr Gerome Breen |
Application 27546
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About
We aim to identify DNA changes associated with body composition, physical and metabolic traits, eating disorders (ED) and obesity. ED share common genetic variants with metabolic traits. Anorexia nervosa (AN) shows an inverse genetic correlation with BMI. BMI is associated with CNS genes.The genetic overlap across ED, BMI, psychiatric disorders, physical diseases and traits may elucidate the underlying biology. Predictive models will seek to identify individuals who are at risk and to develop personalised interventions for ED. The UK Biobank is of considerable value in understanding environmental risk factors, such as physical activity levels and diet patterns. ED and obesity, which has an neuropsychiatric component, are associated with excess morbidity, mortality, increased familial, social and economic burden. AN has the highest mortality rate of any psychiatric disorder. ED are poorly understood. However, neuropsychiatric disorders are genetically influenced. Individuals with a genetic liability face symptom inducing environmental pressures. If these symptoms exceed a certain threshold, this individual may be diagnosed as mentally or physically ill. Identifying genetic, metabolic and environmental risk factors enables healthcare professionals to intervene at any stage to guarantee prevention, diagnosis and treatment. The identification of genetic variants may lead to the development of drugs. We will perform genome-wide association studies, testing DNA variants for their association with body weight, body composition, different traits and disorders. We will examine how these relate to ED. The body imaging data and other measures will be used. This will allow the detection of biological pathways involved in appetite regulation, body composition and metabolic traits disturbed in AN and in obesity. We will include genetic and environmental factors into models to predict case status and severity and will replicate it in the Psychiatric Genomics Consortium data. We will explore the genetic overlap between ED and associated physical disorders. Full cohort4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9088 | Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent | Christopher Hübel (+11) | 2019 | Nature Communications |
| 12024 | Genomics of body fat percentage may contribute to sex bias in anorexia nervosa | Christopher Hübel (+17) | 2018 | American Journal of Medical Genetics Part B Neuropsychiatric Genetics |
| 12880 | One size does not fit all. Genomics differentiates among anorexia nervosa, bulimia nervosa, and binge-eating disorder | Christopher Hübel (+6) | 2021 | International Journal of Eating Disorders |
| 10518 | Persistent thinness and anorexia nervosa differ on a genomic level | Christopher Hübel (+7) | 2023 | European Journal of Human Genetics |
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