| Title: | Causal effects of education on chronic kidney disease: a Mendelian randomization study |
| Journal: | Clinical Kidney Journal |
| Published: | 22 Dec 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34345417/ |
| DOI: | https://doi.org/10.1093/ckj/sfaa240 |
| URL: | https://academic.oup.com/ckj/article-pdf/14/8/1932/39449384/sfaa240.pdf |
Publication 3427
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Abstract
BACKGROUND: Poor socio-economic status, including low education attainment, has been reported in chronic kidney disease (CKD) patients. We aimed to investigate the causal effects of education attainment on the risk of CKD.</p>
METHODS: The study was an observational cohort study including Mendelian randomization (MR) analysis. First, the clinical association between education attainment years as the exposure and prevalent CKD Stages 3-5 as the outcome was investigated by multivariable logistic regression in 308 741 individuals 40-69 years of age from the UK Biobank. MR analysis was performed with a previously reported genetic instrument from a genome-wide association meta-analysis of education attainment. Two-sample MR was performed with summary statistics for CKD in 567 460 individuals with European ancestry in the CKDGen genome-wide association meta-analysis. The findings were replicated by allele score-based MR in 321 260 individuals of white British ancestry in the UK Biobank with quality-controlled genetic data.</p>
RESULTS: Higher education attainment was significantly associated with lower adjusted odds for CKD in the clinical analysis {>17 years versus <16 years, adjusted odds ratio [OR] 0.910 [95% confidence interval (CI) 0.849-0.975]}. The causal estimates obtained by the inverse variance method in the two-sample MR indicated that higher genetically predicted education attainment causally reduced the risk of CKD [OR 0.934 (95% CI 0.873-0.999)]. Allele score-based MR also supported that higher education attainment was causally linked to a decreased risk of CKD [adjusted OR 0.944 (95% CI 0.922-0.966)].</p>
CONCLUSION: The study suggests that higher education attainment causally reduces the risk of CKD development in the general population.</p>
14 Authors
- Sehoon Park
- Soojin Lee
- Yaerim Kim
- Yeonhee Lee
- Min Woo Kang
- Kwangsoo Kim
- Yong Chul Kim
- Seung Seok Han
- Hajeong Lee
- Jung Pyo Lee
- Kwon Wook Joo
- Chun Soo Lim
- Yon Su Kim
- Dong Ki Kim
1 Application
| Application ID | Title |
|---|---|
| 53799 | Impact of genetic and environmental factors on the health-related outcomes in chronic kidney disease patients |
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