| Application: | 15008, The impact of smoking, alcohol and adiposity on health outcomes in the UK Biobank |
| Title: | Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants |
| Size: | 15691 B |
| Archived: | 1 Apr 2021 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 3273
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Notes
Adversity experiences (AEs) are major risk factors for psychiatric illness, and ample evidence suggests that adversity-related changes in brain structure enhance this vulnerability. To achieve greater understanding of the underlying biological pathways, increased convergence among findings is needed. Suggested future directions may benefit from the use of large population samples which may contribute to achieving this goal. We addressed mechanistic pathways by investigating the associations between multiple brain phenotypes and retrospectively reported AEs in early life (child adversity) and adulthood (partner abuse) in a large population sample, using a crosssectional approach.Using a large population cohort, this study demonstrates the value of big datasets in the study of adversity and using automatically preprocessed neuroimaging phenotypes. While retrospective and cross-sectional characteristics limit interpretation, this study demonstrates that self-perceived adversity reports, however nonspecific, may still expose neural consequences, identifiable with increased statistical power.
Application 15008
The impact of smoking, alcohol and adiposity on health outcomes in the UK Biobank
Aim The proposal is to investigate the impact of three classic risk factors (smoking, alcohol and adiposity, each of which can affect many different diseases) on a wide range of health outcomes in UK Biobank (UKB). Of particular interest will be vascular outcomes and cancer along with cognitive performance and mood. This study will contribute to a greater understanding of how these classic risk factors combine to affect population health. Methods The initial focus of this work will be to analyse baseline data comparing risk of major chronic disease according to smoking behaviour, alcohol consumption and adiposity. When re-measurement data become available we will use these to improve the precision of our analyses. When prospective data become available we will extend our analyses to include incidence and mortality. Outcome data of interest will include death, cancer registry data and hospital episode data. When bio-marker data become available we will investigate possible mechanisms underlying the associations of these three risk factors with prevalent and incident outcomes. When genetic data become available we will use these to investigate the interaction between genetic and environmental factors and to further investigate possible mechanisms. Subjects The value of the proposed analyses lies in the statistical power that is available from using the entire UKB cohort. This will enable us to provide the most detailed analyses of these important causes of morbidity and mortality to date
| Lead investigator: | Professor John Gallacher |
| Lead institution: | University of Oxford |
2 related Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 2847 | 15008 | Healthy living and cancer: evidence from UK Biobank | 23 Nov 2020 |
| 2852 | 15008 | Reflection on modern methods: calculating a sample size for a repeatability sub-study to correct for measurement error in a single continuous exposure | 23 Nov 2020 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 3274 | Associations of perceived adverse lifetime experiences with brain structure in UK Biobank participants | Gheorghe DA et al. | 2021 | J Child Psychol Psychiatry |
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