| Title: | Immune-Inflammatory markers and heart failure incidence and mortality: a population-based longitudinal study |
| Journal: | Frontiers in Cardiovascular Medicine |
| Published: | 11 Jun 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42368847/ |
| DOI: | https://doi.org/10.3389/fcvm.2026.1827994 |
| URL: | https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1827994/pdf |
Publication 20765
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Abstract
Background: Inflammation is a crucial pathophysiological driver contributing to the initiation and perpetuation of heart failure (HF). This study conducted a rigorous comparison among six immune-inflammatory indices to evaluate their predictive role for HF incidence and subsequent mortality.</p>
Methods: We analyzed data from 415,263 participants free of HF and 1,952 patients with established HF from the UK Biobank. The markers assessed were the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), aggregate index of systemic inflammation (AISI), inflammatory burden index (IBI), C-reactive protein-albumin-lymphocyte (CALLY) index, and neutrophil-to-lymphocyte ratio (NLR). The outcomes were incident HF and all-cause mortality among HF patients.</p>
Results: Elevated levels of SII, SIRI, AISI, IBI, and NLR showed significant, dose-response relationships with an enhanced likelihood of HF events. The IBI demonstrated the strongest association, with participants in the highest quintile having an 86% higher risk of HF than those in the lowest quintile (HR 1.86, 95% CI: 1.75-1.97). Conversely, a higher CALLY was associated with a lower risk of HF (HR for Q5 vs. Q1: 0.56, 95% CI: 0.53-0.60). Among HF patients, SIRI, AISI, IBI, and NLR had a positive correlation with all-cause mortality, whereas the CALLY was associated with improved survival (HR 0.81, 95% CI: 0.70-0.94). ROC analyses confirmed that IBI provided the superior predictive accuracy for both incident HF and mortality.</p>
Conclusion: Immune-inflammatory markers are significant predictors of HF incidence and prognosis. The IBI emerged as the most robust biomarker, underscoring its utility for risk stratification in primary and secondary HF prevention.</p>
8 Authors
- Siqi Li
- Jie Cai
- Feiyang Zhao
- Liangkai Chen
- Xia Han
- Xue Xiao
- Hui Xiong
- Jinfeng Yang
1 Application
| Application ID | Title |
|---|---|
| 524293 | The Role of Nutrition and Healthy Lifestyles in Metabolic, Cardiovascular, and Aging-Related Diseases: Impacts on Healthy Aging |
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