| Title: | Ancient DNA reveals pervasive directional selection across West Eurasia |
| Journal: | Nature |
| Published: | 15 Apr 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41986721/ |
| DOI: | https://doi.org/10.1038/s41586-026-10358-1 |
Publication 17995
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Abstract
Ancient DNA has transformed our understanding of population history1, but its potential to reveal as much about human evolutionary biology has not been realized because of limited sample sizes and the difficulty of distinguishing sustained rises in allele frequency increasing fitness - directional selection - from shifts due to migrations, population structure, or non-adaptive purifying or stabilizing selection2, 3, 4, 5, 6-7. Here we present a method for detecting directional selection in ancient DNA time-series data that tests for consistent trends in allele frequency change over time, and apply it to 15,836 West Eurasians (10,016 with new data). Previous work has shown that classic hard sweeps driving advantageous mutations to fixation have been rare over the broad span of human evolution8,9. By contrast, in the past ten millennia, we find that many hundreds of alleles have been affected by strong directional selection. We also document one-standard-deviation changes on the scale of modern variation in combinations of alleles that today predict complex traits. This includes decreases in predicted body fat and schizophrenia, and increases in measures of cognitive performance. These effects were measured in industrialized societies, and it remains unclear how these relate to phenotypes that were adaptive in the past. We estimate selection coefficients at 9.7 million variants, enabling study of how Darwinian forces couple to allelic effects and shape the genetic architecture of complex traits.</p>
17 Authors
- Ali Akbari
- Annabel Perry
- Alison R. Barton
- Mohammadreza Kariminejad
- Steven Gazal
- Zheng Li
- Yating Zeng
- Alissa Mittnik
- Nick Patterson
- Matthew Mah
- Xiang Zhou
- Alkes L. Price
- Eric S. Lander
- Ron Pinhasi
- Nadin Rohland
- Swapan Mallick
- David Reich
1 Application
| Application ID | Title |
|---|---|
| 16549 | Components of heritability in a UK Biobank cohort |
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