| Title: | Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study |
| Journal: | BMC Medicine |
| Published: | 22 Aug 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35989356/ |
| DOI: | https://doi.org/10.1186/s12916-022-02460-8 |
| URL: | https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-022-02460-8 |
Publication 14581
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Abstract
Abstract</p>
BackgroundThe relationship between non-alcoholic fatty liver degree as well as non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) remains poorly understood. We aimed to investigate the prospective association of non-alcoholic fatty liver degree as well as NAFLD with incident IBS in a large-scale population-based cohort.MethodsParticipants free of IBS, coeliac disease, inflammatory bowel disease, alcoholic liver disease, and any cancer at baseline from the UK Biobank were included. Non-alcoholic fatty liver degree was measured by a well-validated fatty liver index (FLI), with FLI ≥ 60 as an indicator of NAFLD. Primary outcome was incident IBS. Cox proportional hazard model was used to investigate the associated risk of incident IBS.ResultsAmong 396,838 participants (mean FLI was 48.29 ± 30.07), 153,203(38.6%) were with NAFLD diagnosis at baseline. During a median of 12.4-year follow-up, 7129 cases of incident IBS were identified. Compared with non-NAFLD, NAFLD patients showed a 13% higher risk of developing IBS (HR = 1.13, 95%CI: 1.05-1.17) after multivariable adjustment. Compared with the lowest, the highest FLI quartile was associated with a significantly increased risk of IBS (HRQ4 VS Q1 = 1.21, 1.13-1.30, Ptrend < 0.001). Specifically, the positive association between non-alcoholic fatty liver degree and IBS was also observed by per SD change of FLI (adjusted HR = 1.08, 1.05-1.10). Further sensitivity analysis and subgroup analysis indicated similar results, with the positive association particularly observed in females, but not in males.ConclusionsHigh degree of non-alcoholic fatty liver as well as non-alcoholic fatty liver disease is associated with increased risk of incident IBS. Further studies are warranted to confirm the findings and elucidate the underlying biological mechanisms.</p>
8 Keywords
- Cohort Studies
- Female
- Humans
- Irritable Bowel Syndrome
- Male
- Non-alcoholic Fatty Liver Disease
- Prospective Studies
- Risk Factors
7 Authors
- Shanshan Wu
- Changzheng Yuan
- Zhirong Yang
- Si Liu
- Qian Zhang
- Shutian Zhang
- Shengtao Zhu
1 Application
| Application ID | Title |
|---|---|
| 74444 | Common risk factors and prognosis of inflammatory bowel disease and irritable bowel syndrome |
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