| Title: | Common risk factors and prognosis of inflammatory bowel disease and irritable bowel syndrome |
| Lead Institution: | Beijing Friendship Hospital, Capital Medical University |
| Principal investigator: | Professor Shanshan Wu |
Application 74444
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About
Aims: Our study aims to investigate potential risk factors and prognosis of inflammatory bowel disease and irritable bowel syndrome diseases. Scientific rationale: These two categories of diseases affect a large and growing population worldwide. However, the potential lifestyle and environment risk factors are not exactly clear until now. Current studies suggest that some lifestyle factors, such as diet and physical activity, may play an important role in the development of these two categories of diseases. Meanwhile, the prognosis of these two categories of diseases, especially the long-term prognosis is still lack of evidence. Whether inflammatory bowel disease and irritable bowel syndrome diseases are associated with increased risk of multiple health-related outcomes, such as cancer, metabolic diseases, mental disorders and mortality, is still needed to investigate and assess in the large-scale, prospective, long-term cohort study. Project duration: This complicated project includes several independent analyses. We expect to achieve some initial milestones in the next 3 years. Public health impact: Our study may promote public health policy priorities by focusing on common lifestyle and environment risk factors of inflammatory bowel disease and irritable bowel syndrome diseases. Evidences on the risk factors and prognosis of these diseases may inform healthcare providers to ensure the long-term survival of those patients, and inspires new clinical practices in disease treatment.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 11178 | Coffee and tea intake with long-term risk of irritable bowel syndrome: a large-scale prospective cohort study | Shanshan Wu (+6) | 2023 | International Journal of Epidemiology |
| 9280 | Frailty and pre-frailty with long-term risk of elderly-onset inflammatory bowel disease: A large-scale prospective cohort study | Qian Zhang (+7) | 2023 | Annals of Epidemiology |
| 10853 | Frailty status and risk of irritable bowel syndrome in middle-aged and older adults: A large-scale prospective cohort study | Shanshan Wu (+5) | 2022 | EClinicalMedicine |
| 7200 | Irritable Bowel Syndrome and Long-Term Risk of Cancer: A Prospective Cohort Study Among 0.5 Million Adults in UK Biobank | Shanshan Wu (+8) | 2022 | The American Journal of Gastroenterology |
| 10069 | Ultra-Processed Food Consumption and Long-Term Risk of Irritable Bowel Syndrome: A Large-Scale Prospective Cohort Study | Shanshan Wu (+5) | 2024 | Clinical Gastroenterology and Hepatology |
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