| Title: | Impact of hyperuricemia on CKD risk beyond genetic predisposition in a population-based cohort study |
| Journal: | Scientific Reports |
| Published: | 9 Aug 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39122851/ |
| DOI: | https://doi.org/10.1038/s41598-024-69420-5 |
| URL: | https://www.nature.com/articles/s41598-024-69420-5.pdf |
Publication 12979
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Abstract
The bidirectional effect of hyperuricemia on chronic kidney disease (CKD) underscores the importance of hyperuricemia as a risk factor for CKD. We evaluated the effect of hyperuricemia on the presence and development of CKD after considering genetic background by calculating polygenic risk scores (PRSs). We employed genome-wide association study summary statistics - excluding the United Kingdom Biobank (UKB) datasets among published CKD Gen Consortium papers - to calculate the PRSs for CKD in white background subjects. To validate PRS performance, we divided the UKB into two datasets to validate and test the data. We used logistic regression analysis to evaluate the association between hyperuricemia and CKD, and performed Kaplan-Meier survival analysis exclusively for subjects with available follow-up data. In total, 438,253 clinical data and 4,307,940 single nucleotide polymorphisms from 459,155 samples were included. We observed a significant positive association between PRS and CKD and the presence and development of CKD. Hyperuricemia significantly increased CKD risk (adjusted odds ratio 1.55, 95% confidence interval 1.48-1.61). The impact of hyperuricemia on CKD was maintained irrespective of PRS range. In addition, negative interaction between hyperuricemia and PRS for CKD was found. Survival analysis indicates that the presence of hyperuricemia significantly increased the risk of CKD development. The PRS for CKD thoroughly reflects the risk of CKD development. Hyperuricemia is a significant indicator of CKD risk, even after incorporating the genetic risk score for CKD. Irrespective of genetic risk, patients with a prospective risk of developing CKD require uric acid monitoring and management.</p>
15 Keywords
- Adult
- Aged
- Cohort Studies
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Hyperuricemia
- Male
- Middle Aged
- Multifactorial Inheritance
- Polymorphism, Single Nucleotide
- Renal Insufficiency, Chronic
- Risk Factors
- United Kingdom
13 Authors
- Yaerim Kim
- Jinyeon Jo
- Yunmi Ji
- Eunjin Bae
- Kwangbae Lee
- Jin Hyuk Paek
- Kyubok Jin
- Seungyeup Han
- Jung Pyo Lee
- Dong Ki Kim
- Chun Soo Lim
- Sungho Won
- Jeonghwan Lee
1 Application
| Application ID | Title |
|---|---|
| 53799 | Impact of genetic and environmental factors on the health-related outcomes in chronic kidney disease patients |
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