| Title: | Identification of genetic components underlying cerebrovascular diseases and their related outcomes |
| Lead Institution: | Massachusetts General Hospital |
| Principal investigator: | Dr Christopher Anderson |
Application 36993
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About
Aim: The main aim of our study is to do genetic association study with stroke in order to identify its genetic risk factors. Rationale: Genetics is such a powerful tool for identifying disease etiology. We will understand key mechanism of stroke based on the findings from this proposed genetic study. Duration: This study will take 3 years. Impact: Better understanding stroke mechanism by genetics provides promising grounds for implications for clinical practice and development of therapeutic approaches for the disease.6 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 11100 | A Genomic Risk Score Identifies Individuals at High Risk for Intracerebral Hemorrhage | Evangelos Pavlos Myserlis (+12) | 2023 | Stroke |
| 7949 | Genetic Risk Score Improves Risk Stratification for Anticoagulation-Related Intracerebral Hemorrhage | Ernst Mayerhofer (+6) | 2023 | Stroke |
| 9382 | Genetic and Nongenetic Components of Stroke Family History: A Population Study of Adopted and Nonadopted Individuals | Ernst Mayerhofer (+6) | 2023 | Journal of the American Heart Association |
| 11646 | Genetic variation supports a causal role for valproate in prevention of ischemic stroke | Ernst Mayerhofer (+7) | 2023 | International Journal of Stroke |
| 12365 | Genetically predicted on-statin LDL response is associated with higher intracerebral haemorrhage risk | Ernst Mayerhofer (+8) | 2022 | Brain |
| 12041 | Genetically proxied HTRA1 protease activity and circulating levels independently predict risk of ischemic stroke and coronary artery disease | Rainer Malik (+12) | 2024 | Nature Cardiovascular Research |
Enabling scientific discoveries that improve human health