| Title: | Myeloproliferative neoplasms and clonal haematopoiesis |
| Lead Institution: | University of Southampton |
| Principal investigator: | Professor Nicholas Cross |
Application 35273
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About
We aim to (i) identify common genetic variation that predisposes to chronic myeloproliferative neoplasms (a type of blood cancer) and (ii) understand the relationship between age-related clonal haematopoiesis and the development of a myeloproliferative phenotype. This study will improve our understanding of genetic factors that contribute to the onset and severity of myeloproliferative neoplasms. We anticipate that our findings will improve methods to diagnose and stage these disorders, thus providing a framework for more personalised management. We will perform a genome wide association study by comparing genetic variation in patients with chronic myeloproliferative neoplasms (cases) and the Biobank population (controls). In addition we will analyse the Biobank population for evidence of somatically acquired clonal abnormalities, and relate this information to constitutional genetic factors as well as any available information on blood counts.1 Return
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3685 | 35273 | Clonal myelopoiesis in the UK Biobank cohort: ASXL1 mutations are strongly associated with smoking | 29 Jul 2021 |
4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 11365 | Age-related loss of chromosome Y is associated with levels of sex hormone binding globulin and clonal hematopoiesis defined by TET2, TP53, and CBL mutations | Ahmed A Z Dawoud (+2) | 2023 | Science Advances |
| 3686 | Clonal myelopoiesis in the UK Biobank cohort: ASXL1 mutations are strongly associated with smoking | Ahmed A. Z. Dawoud (+2) | 2020 | Leukemia |
| 17030 | Genome-wide analysis defines genetic determinants of MPN subtypes and identifies a sex-specific association at CDH22/CD40 | William J Tapper (+19) | 2025 | Blood |
| 12597 | Predicting Pancreatic Cancer in the UK Biobank Cohort Using Polygenic Risk Scores and Diabetes Mellitus | Shreya Sharma (+3) | 2022 | Gastroenterology |
Enabling scientific discoveries that improve human health