About
The mediating mechanisms linking anthropometric and lifestyle risk factors with cancer development and survival remain unclear. We aim to investigate the potential mediating roles of metabolic factors (including biomarkers and intermediate conditions and diseases) on the association between risk factors (e.g. fat mass, diet, physical activity) and subsequent cancer diagnosis, death and survival by cancer type. The proposed project aims to understand the mechanisms that underpin the association of risk factors with cancer development and progression, which is consistent with UK Biobank's mission of health-related research that is in the interest of the public good. In the first stage of this project we will run prospective analyses to assess the associations of potential risk factors with risk of, and death from, specific cancers. If there are sufficient cases and available information on tumour characteristics, we will split tumours into subtypes. We will also assess the association between the potential risk factors and each of the possible mediators, as well as the prospective associations between the mediators and cancer risk. Finally, we will estimate the mediation effects of the individual mediators in the associations between risk factors and cancer risk. We intend to include all participants of the UK Biobank cohort.
5 Returns
| Return ID | App ID | Description | Archive Date |
|---|
| 3602 | 24494 | Circulating Insulin-like Growth Factor-I Concentrations and Risk of 30 Cancers: Prospective Analyses in UK Biobank | 29 Jun 2021 |
| 4423 | 24494 | Description of the updated nutrition calculation of the Oxford WebQ questionnaire and comparison with the previous version among 207,144 participants in UK Biobank | 27 Jun 2022 |
| 2380 | 24494 | Evaluation of the New Individual Fatty Acid Dataset for UK Biobank: Analysis of Intakes and Sources in 207,997 Participants | 3 May 2024 |
| 3604 | 24494 | Health impacts and environmental footprints of diets that meet the Eatwell Guide recommendations: analyses of multiple UK studies | 29 Jun 2021 |
| 3603 | 24494 | Meat intake and cancer risk: prospective analyses in UK Biobank | 29 Jun 2021 |
13 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|
| 12382 | Adiposity and risk of prostate cancer death: a prospective analysis in UK Biobank and meta-analysis of published studies | Aurora Perez-Cornago (+4) | 2022 | BMC Medicine |
| 10384 | Associations between food group intakes and circulating insulin-like growth factor-I in the UK Biobank: a cross-sectional analysis | Cody Z. Watling (+10) | 2022 | European Journal of Nutrition |
| 11083 | Associations between types and sources of dietary carbohydrates and cardiovascular disease risk: a prospective cohort study of UK Biobank participants | Rebecca K. Kelly (+9) | 2023 | BMC Medicine |
| 10309 | Associations of intakes of total protein, protein from dairy sources, and dietary calcium with risks of colorectal, breast, and prostate cancer: a prospective analysis in UK Biobank | Cody Z. Watling (+8) | 2023 | British Journal of Cancer |
| 3603 | Circulating Insulin-like Growth Factor-I Concentrations and Risk of 30 Cancers: Prospective Analyses in UK Biobank | Anika Knuppel (+10) | 2020 | Cancer Research |
| 9818 | Evaluation of the New Individual Fatty Acid Dataset for UK Biobank: Analysis of Intakes and Sources in 207,997 Participants | Rebecca K. Kelly (+9) | 2022 | Nutrients |
| 3605 | Health impacts and environmental footprints of diets that meet the Eatwell Guide recommendations: analyses of multiple UK studies | Scheelbeek P et al. | 2020 | BMJ Open |
| 10615 | Intakes of major food groups in China and UK: results from 100,000 adults in the China Kadoorie biobank and UK biobank | Keren Papier (+14) | 2022 | European Journal of Nutrition |
| 9565 | Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study | Keren Papier (+8) | 2021 | BMC Medicine |
| 3604 | Meat intake and cancer risk: prospective analyses in UK Biobank | Knuppel A et al. | 2020 | Int J Epidemiol |
| 7862 | Prospective analysis reveals associations between carbohydrate intakes, genetic predictors of short-chain fatty acid synthesis, and colorectal cancer risk | Cody Z. Watling (+8) | 2023 | Cancer Research |
| 12342 | Risk of Cancer in Regular and Low Meat-Eaters, Fish-Eaters, and Vegetarians: A Prospective Analysis of UK Biobank Participants | Cody Watling (+8) | 2022 | Current Developments in Nutrition |
| 12513 | Risk of cancer in regular and low meat-eaters, fish-eaters, and vegetarians: a prospective analysis of UK Biobank participants | Cody Z. Watling (+8) | 2022 | BMC Medicine |
