| Title: | Associations between immune-mediated diseases (IMDs) and the risk of HPV-associated diseases: a UK Biobank cohort analysis |
| Journal: | BMJ Open |
| Published: | 19 Sep 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37730406/ |
| DOI: | https://doi.org/10.1136/bmjopen-2023-072249 |
| URL: | https://bmjopen.bmj.com/content/bmjopen/13/9/e072249.full.pdf |
Publication 9520
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Abstract
OBJECTIVES: To systematically assess the associations between various immune-mediated diseases (IMDs) and human papillomavirus (HPV)-associated diseases.</p>
DESIGN: Retrospective cohort study.</p>
SETTING: UK Biobank.</p>
PARTICIPANTS: A total of 500 371 subjects aged 40-69 years were eligible for the analysis, after excluding those with prevalent HPV-associated diseases at baseline and those who had withdrawn their informed consent or lacked information on sex.</p>
EXPOSURE: Eighty IMDs (involving allergic/atopic diseases, autoimmune diseases, immunodeficiency diseases, etc) were identified in the UK Biobank.</p>
PRIMARY AND SECONDARY OUTCOME MEASURES: The main outcome was the incidence of HPV-associated diseases (including warts and malignancies of the cervix, oropharynx, anus, penis, vulva and vagina). Cox proportional hazards model was used to estimate HRs and 95% CIs with particular adjustment for sexual behaviours. We also conducted subgroup analyses based on benign and malignant status, and anatomical sites of HPV-associated diseases, respectively.</p>
RESULTS: During a median of 12.0 years of follow-up, 2244 cases out of 500 371 subjects developed HPV-associated diseases. Overall, participants with IMDs had a higher risk of HPV-associated diseases than their controls after adjustment for sexual behaviours and other potential confounders (female: HR=1.90, 95% CI=1.66 to 2.17, p<0.001; male: HR=1.66, 95% CI=1.41 to 1.97, p<0.001). Additionally, eight individual IMDs in women (eg, asthma: HR=1.76, 95% CI=1.47 to 2.11, p<0.001) and three in men (eg, chronic nephritic syndrome: HR=6.05, 95% CI=3.32 to 11.04, p<0.001) were associated with increased risk of HPV-associated diseases. Subgroup analyses revealed significant IMD differences between benign and malignant subgroups as well as between oropharyngeal and anogenital subgroups.</p>
CONCLUSION: In this large retrospective cohort study, IMDs were significantly associated with an elevated risk of HPV-associated diseases. Besides, gender-specific and region-specific associations were also observed between individual IMDs and HPV-associated diseases.</p>
9 Keywords
- Biological Specimen Banks
- Female
- Human Papillomavirus Viruses
- Humans
- Hypersensitivity
- Male
- Papillomavirus Infections
- Retrospective Studies
- United Kingdom
13 Authors
- Lan Feng
- Ke Qiu
- Yufang Rao
- Tao Shu
- Yao Song
- Danni Cheng
- Minzi Mao
- Junhong Li
- Ziyan Zhang
- Xiaoyu Wang
- Xinghan Zeng
- Yu Zhao
- JianJun Ren
1 Application
| Application ID | Title |
|---|---|
| 69718 | Multi-omic analyses of otorhinolaryngology-related disorders |
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